Do unliganded thyroid hormone receptors have physiological functions?
نویسندگان
چکیده
منابع مشابه
Do unliganded thyroid hormone receptors have physiological functions?
Thyroid hormone (TH) is required for the development of vertebrates and exerts numerous homeostatic functions in adults. TH acts through nuclear receptors which control the transcription of target genes. Unliganded and liganded thyroid hormone receptors (TRs) have been shown to exert opposite effects on the transcription of target genes in vitro. However, the occurance of an aporeceptor activit...
متن کاملUnliganded thyroid hormone receptor function: amphibian metamorphosis got TALENs.
Thyroid hormones (THs) are capital for development and cell homeostasis. THs act by regulating gene expression through TH receptors (TRs), which are transcription factors that belong to the nuclear receptors superfamily (1). THs and TRs are versatile players because they can not only up-regulate, but also down-regulate, gene expression in target cells. It is generally believed that TRs mediate ...
متن کاملUnliganded thyroid hormone receptor 1 impairs adult hippocampal neurogenesis
Thyroid hormone regulates adult hippocampal neurogenesis, a process involved in key functions, such as learning, memory, and mood regulation. We addressed the role of thyroid hormone receptor TR 1 in adult hippocampal neurogenesis, using mice harboring a TR 1 null allele (TR 1 / ), overexpressing TR 1 6-fold (TR 2 / ), and a mutant TR 1 (TR 1 ) with a 10-fold lower affinity to the ligand. While...
متن کاملEmbryonic estrogen receptors: do they have a physiological function?
In normal estrogen target tissues, estrogen action is mediated through a specific nuclear transcription factor, the estrogen receptor (ER). The site of estrogen action in the developing organism is therefore determined by cells that contain ER and other necessary tissue and gene-specific components for estrogen-mediated transcription. Immunocytochemical methods were used to determine the cellul...
متن کاملDifferent functions for the thyroid hormone receptors TR and TR in the control of thyroid hormone production and postnatal development
The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotype...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2003
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0310009